In vitro immunomonitoring of insect venom-allergic patients on immunotherapy
نویسندگان
چکیده
Objective Sting challenge is the gold standard method to evaluate the therapeutic efficiency of allergen specific immunotherapy (ASIT) in hymenoptera venom allergic patients. Unfortunately, this method is risky, expensive and time consuming. Therefore, the development of an in vitro method is desirable. Recently the basophil activation test (BAT) performed with natural venom has been shown to be a promising method. We aimed to improve the benefit of BAT technology by applying the panel of recombinant allergens Ves v 1, Ves v 2, Ves v 3 and Ves v 5.
منابع مشابه
Mastocytosis and insect venom allergy.
PURPOSE OF REVIEW To analyse the association of systemic allergic hymenoptera sting reactions with mastocytosis and elevated baseline serum tryptase and to discuss diagnosis and treatment in patients with both diseases. RECENT FINDINGS In recent large studies on patients with mastocytosis a much higher incidence of severe anaphylaxis following hymenoptera stings than in the normal population ...
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OBJECTIVE At present, no reliable in vitro test is available to monitor the success of specific venom immunotherapy (VIT) in preventing insect venom anaphylaxis. We investigated usefulness of the basophil activation test (BAT) in predicting the outcome of sting challenge in bee venom-allergic patients after VIT. PATIENTS AND METHODS Twenty-one patients with bee venom anaphylaxis at the end of...
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BACKGROUND Children are thought to "outgrow" the allergy to insect stings, but there are no reports documenting the natural history of this reaction. We studied the outcome of allergic reactions to insect stings in childhood 10 to 20 years afterward in patients who had not received venom immunotherapy and in those who had been treated. METHODS Between 1978 and 1985, we diagnosed allergic reac...
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N Engl J Med 2004;351:668-74. Copyright © 2004 Massachusetts Medical Society. background Children are thought to “outgrow” the allergy to insect stings, but there are no reports documenting the natural history of this reaction. We studied the outcome of allergic reactions to insect stings in childhood 10 to 20 years afterward in patients who had not received venom immunotherapy and in those who...
متن کاملWhich immunotherapy product is better for patients allergic to Polistes venom? A laboratory and clinical study
BACKGROUND Venom immunotherapy (VIT) is highly effective in preventing allergic reactions to insect stings, but the appropriate venom must be used to achieve clinical protection. In patients with multiple positive results to venoms, molecular allergy diagnostics or CAP-inhibition may identify the causative venom. Concerning allergy to venom from Polistes spp. it has been proposed that only the ...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2014